منابع مشابه
Harnessing Big Data for Precision Medicine: Infrastructures and Applications
Precision medicine is a health management approach that accounts for individual differences in genetic backgrounds and environmental exposures. With the recent advancements in high-throughput omics profiling technologies, collections of large study cohorts, and the developments of data mining algorithms, big data in biomedicine is expected to provide novel insights into health and disease state...
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Recent advances in human pluripotent stem cells (hPSCs) open new doors for therapeutics of motor neuron (MN)-associated neurodegenerative diseases. However, the MN differentiation process is not yet completely understood. In this Viewpoint, we stress the concept of designing synthetic cell culture surfaces with precisely controlled mechanical properties (such as rigidity) to improve the efficie...
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Mechanical stimulus is of upmost importance in tissues developmental and regeneration processes as well as in maintaining body homeostasis. Classical physiological reactions encompass an increase of blood vessel diameter upon exposure to high blood pressure, or the expansion of cortical bone after continuous high-impact exercise. At a cellular level, it is well established that extracellular st...
متن کاملHarnessing Host Defenses to HIV
The battle against HIV is beingwaged onmany fronts, fromprevention efforts to the development of new antiviral therapies. Although the body’s immune system is ultimately overcome if an infection is left untreated, there are numerous lines of host defense that, when augmented, could counter HIV’s relentless assault. This Select highlights recent advances in understanding the interplay between HI...
متن کاملHarnessing entropy to heal polymers
Peroxyl radicals have a key role in the degradation of volatile organics in the atmosphere, as well as the oxidation of cellular lipids and other integral biomolecules. The excited electronic (B) state of alkylperoxyl radicals is dissociative and lies reliably in the ultraviolet region. Arylperoxyl radicals, on the other hand, are predicted to have a dissociative state accessible within the vis...
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ژورنال
عنوان ژورنال: Nature
سال: 1975
ISSN: 0028-0836,1476-4687
DOI: 10.1038/258558a0